Minimally invasive diagnostics

• Fluorescence-based sensors
• Absorption-based sensors
• Optical fibre sensors
• Microdialysis

For more detailed information please consult the P4L database.

Case study: Microdialysis-assisted optical fibre pH sensor

Microdialysis for minimally invasive diagnostics

• Extraction of interstitial fluid with a microdialysis catheter is a less-invasive
• Continuous measurement of chemical and biochemical analytes without blood loss and with the reduction of painful stress

Optical pH sensing fibre sensor

• Optical pH sensors based on absorption
• Immobilisation of an pH indicator on the internal wall of glass capillary
• Optical interrogation of the glass capillary with optical fibres

Clinical validation

• Continuous monitoring of pH
• Clinical validation on animals
• Development of a model to create a situation of stress
• Subcutaneous tissue as a promising alternative site for monitoring stress in vivo