Minimally invasive diagnostics

  • Fluorescence-based sensors
  • Absorption-based sensors
  • Optical fibre sensors
  • Microdialysis

For more detailed information please consult the P4L database.

Case study: Microdialysis-assisted optical fibre pH sensor

Microdialysis for minimally invasive diagnostics

  • Extraction of interstitial fluid with a microdialysis catheter is a less-invasive
  • Continuous measurement of chemical and biochemical analytes without blood loss and with the reduction of painful stress
Microdialysis for minimally invasive diagnostics

Optical pH sensing fibre sensor

  • Optical pH sensors based on absorption
  • Immobilisation of an pH indicator on the internal wall of glass capillary
  • Optical interrogation of the glass capillary with optical fibres
Optical pH sensing fibre sensor

Clinical validation

  • Continuous monitoring of pH
  • Clinical validation on animals
  • Development of a model to create a situation of stress
  • Subcutaneous tissue as a promising alternative site for monitoring stress in vivo
Clinical validation